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Message History

Protein tyrosine phosphatase 1B (PTP1B) is a long-standing target for diabetes and other diseases. But as we’ve written previously, it is challenging to drug due to its small and highly charged active site, which is conserved among ...

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Back in 2009 we highlighted a paper, “Escape from flatland,” suggesting that molecules with higher fractions of sp3-hybridized (ie, non-aromatic) carbons are more likely to become drugs. This hypothesis has been

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Earlier this year we highlighted a study that compared the affinities of kinase inhibitors for isolated proteins vs those same proteins in cells and found differences – sometimes dramatic. A new open-access

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Differential scanning fluorimetry (DSF), also known as a thermal shift assay, is one of the most common techniques for fragment screening according to the most recent methods poll on Practical Fragments. This popularity is in...

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