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Diagnostic Reasoning Exercise / Teaching Case
A previously healthy 16-year-old girl developed sudden expressive aphasia, dysarthria, and right-sided weakness while playing video games. Emergency stroke evaluation demonstrated a left MCA occlusion with an NIHSS score of 11. Following thrombolytic therapy and thrombectomy, rapid neurologic improvemen...
Expert Commentary / Peer Perspective
For more than two decades, findings from the Women’s Health Initiative and the HABITS trial have influenced prescribing patterns for menopausal hormone therapy (MHT). This review argues that subsequent analyses, formulation-specific findings, long-term follow-up, and evolving regulatory guidance support a more i...
Expert Commentary / Peer Perspective
This JNP review argues that many frail older adults remain exposed to intensive diabetes treatment strategies despite evidence supporting individualized glycemic goals and deprescribing approaches. The authors emphasize that hypoglycemia, falls, hospitalization, cognitive impairment, and treatment burde...
Observational Association Only Evidence
A comparative study in adults with type 2 diabetes found GLP-1 receptor agonists were associated with increased risk for nonscarring alopecia versus both SGLT-2 and DPP-4 inhibitors. The reported association persisted across sensitivity analyses, although absolute event rates were low.
Clinical Con...Expert Commentary / Peer Perspective
Patients are increasingly asking whether GLP-1 therapy increases penile size. Experts cited in the article attribute reported changes primarily to weight-loss related body composition changes and improved erectile quality, while available evidence remains limited and mixed.
Patient Counseling Points ...