F1000Research

Background Cancer is one of the most significant global health challenges. Cytogenetic techniques are used as biomarkers of cancer risk to detect DNA damage and chromosomal abnormalities. Objective This study aimed to evaluate the influence of chemotherapy on genetic stability in cancer patients by applying Micronucleus and Comet assays as indicators of DNA and chromosomal alter...

Background Cancer is one of the most significant global health challenges. Cytogenetic techniques are used as biomarkers of cancer risk to detect DNA damage and chromosomal abnormalities. Objective This study aimed to evaluate the influence of chemotherapy on genetic stability in cancer patients by applying Micronucleus and Comet assays as indicators of DNA and chromosomal alter...

Background The Association of Southeast Asian Nations (ASEAN) has developed a distinctive diplomatic approach known as the “ASEAN Way,” characterized by consensus-building, non-interference, and informal dialogue. This approach has played a significant role in shaping regional identity and maintaining peace in Southeast Asia, despite increasing geopolitical and transnational cha...

Background Infertility is a global health issue affecting approximately 15% of couples, with male factors contributing to nearly half of the cases. Azoospermia remains a major challenge in male infertility diagnosis and treatment. Current diagnostic methods rely on invasive techniques such as testicular biopsy, which carry risks of tissue damage. MicroRNAs (miRNAs), small non-co...

The Indonesian government has invested heavily in digital transformation to address persistent challenges in public service delivery, financial accountability, and bureaucratic efficiency. Despite growing adoption of technologies such as artificial intelligence, big data analytics, and e-government platforms, a systemic synthesis of how these digital tools collectively reshape g...