Acta Pharmacologica Sinica

Hepatoblastoma (HB) is the most common malignant liver tumor in children. One-fifth of patients exhibit a poor prognosis due to resistance to conventional chemotherapy, which typically includes doxorubicin. One of the underlying mechanisms is drug efflux through the MDR1 export pump. This study aims to explore pharmacological strategies for sensitizing HB by inhibiting MDR1. A p...

The authors would like to apologize for the errors in the published images of Figure 1 and Figure 7. Figure 1a and the band of cyβ-actin and TLR4 in Figure 7 were corrected due to the unintentional misassembly of figures. The misnomered nβ-actin in Figure 7 should be marked as histone H3. All the relative protein levels were revised accordingly.

Allicin, a bioactive compound derived from garlic, exhibits therapeutic potential against metabolic disorders but is hindered by instability and a pungent odor, limiting its clinical application. This study develops an allicin oleogel (OG) formulation, leveraging molecular interactions with unsaturated fatty acids and gelators to stabilize allicin and mitigate its odor for trans...

Dopamine (DA) has shown antitumor potential and is known to modulate immune responses under physiological conditions; however, its specific immunomodulatory role in cancer immunotherapy remains poorly defined. Triple-negative breast cancer (TNBC) is an aggressive malignancy with strong stemness properties and a limited response to immune checkpoint inhibitors (ICIs). Cancer stem...

Hepatoblastoma (HB) is the most common malignant liver tumor in children. One-fifth of patients exhibit a poor prognosis due to resistance to conventional chemotherapy, which typically includes doxorubicin. One of the underlying mechanisms is drug efflux through the MDR1 export pump. This study aims to explore pharmacological strategies for sensitizing HB by inhibiting MDR1. A p...